Penelitian dan pengembangan ini bertujuan untuk mengembangkan media ajar berupa aplikasi berbasis android pada materi virus kelas X SMA dan untuk mengetahui validitas, kepraktisan, serta keefektifan terhadap media yang dikembangkan. Penelitian ini termasuk jenis penelitian Research and Development dengan menggunakan model 4D yang terdiri dari 4 tahapan yaitu Define (Pendefinisian), Design (Perancangan), Development (Pengembangan), dan Dissemination (Penyebaran). Penelitian ini dilaksanakan di SMA Negeri 3 Majene, Kecamatan Banggae Timur, Kabupaten Majene, Provinsi Sulawesi Barat. Subjek penelitian kelas X MIPA 3 yang berjumlah 28 siswa dan guru biologi yang berjumlah 2 orang. Penilaian validitas media pembelajaran berbasis android pada materi virus divalidasi oleh 2 validator ahli dengan menggunakan lembar validasi ahli media dan ahli materi dengan memperoleh nilai rata-rata 4,6 yang termasuk dalam kategori sangat valid. Hasil kepraktisan media menggunakan angket respon guru dan angket respon siswa. Hasil analisis angket menunjukkan nilai dari respon siswa 85,9% yang memperoleh kategori sangat praktis dan nilai dari respon guru 87,9% yang memperoleh kategori sangat praktis. Hasil keefektifan media pembelajaran berbasis android menggunakan tes hasil belajar diperoleh 89,2% berada pada kriteria sangat efektif. Demikian media pembelajaran berbasis android dinyatakan valid, praktis dan efektif untuk digunakan sebagai media pembelajaran.

This research and development aims to develop teaching media in the form of an Android-based application on class X virus material and to determine its validity, practicality and effectiveness. This type of research is Research and Development with a 4D model which consists of 4 stages, namely define, design, development and dissemination. This research was carried out at SMA Negeri 3 Majene, East Banggae District, Majene Regency, West Sulawesi Province. The research subjects for class X MIPA 3 were 28 students and 2 biology teachers. The assessment of the validity of Android-based learning media on viral material was validated by 2 expert validators using media expert validation sheets and material experts obtained an average score of 4,6 which is included in the very valid category. Media practicality results using teacher response questionnaires and student response questionnaires. The results of the questionnaire analysis showed that the value of student responses was 85,9% which was in the very practical category and the value of teacher responses was 87,9% which was in the very practical category. The results of the effectiveness of Android-based learning media using learning outcomes tests were obtained at 89,2%, which is in the very effective criteria. Thus, Android-based learning media is declared valid, practical and effective for use as learning media.